The Gut Microbiome–Human Body Symbiosis: Relevance of the Ubiquitous Microbial Community on Health and Development
There appears to be a collaborative nexus between the human body and its resident microbes. Research shows strong associations between this parallel universe of microorganisms and our overall health, immunity, and behavior. The human microbiome consists of microbes that flourish in different parts of the body. Our gut with all its projections spans nearly 7 kilometers in length and contains the largest number of microorganisms within the human body. An imbalance in the gut microbiome is strongly associated with allergies, metabolic diseases (eg, diabetes, obesity), neurological conditions (eg, depression, autism), respiratory diseases, liver diseases, and cancer. The development of the gut microbiome is a dynamic process that begins either during gestation or at birth and continuously evolves with human growth into adulthood. The gut microbiome is part of an intricate metabolic and signaling network in the human body. It communicates through biochemical pathways or axes with the skin, brain, lungs, kidneys, breast, and liver. A key motivation behind gut microbiome research is to confirm the cause-and-effect role of the gut microbiota on host health homeostasis. Today, gut microbiome research is generating excitement due to its potential to prevent and treat several interrelated health conditions. Conclusive evidence of the role played by the gut microbiome on human health will furnish new avenues of treatment and better insights into the influence of diet, environment, antibiotics, and genetics on the body. This article, the first of a two-part review, will discuss the relevance of the gut microbiome and its prominent constituents, the developmental trajectory of the gut microbiome from infancy to adulthood and its mutualistic relationship with the human host.
How to Cite
Authors of manuscripts accepted for publication retain copyright in their work but are required to grant to AMWA exclusive worldwide first publication rights and further grant a nonexclusive license for other uses of the manuscript for the duration of their copyright as outlined in the Agreement on Authors' Rights and Responsibilities. In the same agreement, authors are required to confirm that the material submitted for publication, both in its paper and electronic versions, including reproductions of other works (eg, photographs, maps, etc.) does not infringe upon any existing copyright.
Any reproduction within two years following the date of publication requires the permission of the Editor-in-Chief of the AMWA Journal.
Contact firstname.lastname@example.org for all requests for reuse.